Pirfenidone induced liver injury: Drug safety alert from Norwegian Medicines Agency

Drug Safety Alert, Global Safety Alerts, Norwegian Medicines Agency, Voluntary ADR reporting, , , ,

Pirfenidone used in the treatment of idiopathic pulmonary fibrosis (scarring of the lung tissue). It is an inhibitor of transforming growth factor (TGF)-beta (a factor which is involved in the proliferation and differentiation of cells) and it also inhibits the TNF-Alpha. Norway health authority (Norwegian Medicines Agency) identified a new safety alert for pirfenidone from…

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Lack of Heparin drug efficacy due to interaction with Andexane alpha

Drug Safety Alert, Global Safety Alerts, Medicinal Product Updates, Norwegian Medicines Agency, Pharmacovigilance, , ,

Norwegian Medicines Agency (health authority of Norway) published a drug safety alert of drug ineffectiveness for heparin due to interaction with andexane alpha. To foster awareness, this significant safety information is disseminated to health care professionals for early implementation of risk minimizing measures. Andexanet alpha is a recombinant modified factor Xa protein for the reversal…

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